Overview of Selected Chemical Compounds and Intermediates
Overview of Selected Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity related to bortezomib, a proteasome inhibitor Employed in the remedy of many myeloma. Its synthesis or review is important for making certain the purity and protection in the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor from the synthesis of abiraterone acetate, a drug Employed in the remedy of prostate cancer by inhibiting androgen production.
Imatinib Intermediate (CAS NO. 152460-ten-1): A vital compound from the synthesis of imatinib, a drug that targets certain kinds of most cancers, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats various cancers such as breast, lung, and prostate cancer.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates in the synthesis of gemcitabine, an anti-cancer drug. Their research is important for optimizing the creation approach and guaranteeing higher purity.
Lapatinib Intermediate (CAS NO. 231278-84-five): Lapatinib is applied to treat breast most cancers, and these intermediates are associated with its output.
Fulvestrant Intermediates: Fulvestrant is really an estrogen receptor antagonist used in the cure of breast cancer. A variety of intermediates assist in the synthesis of this drug.
Paclitaxel Aspect Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in dealing with cancers like ovarian, breast, and lung most cancers.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the therapy of colorectal most cancers and tiny mobile lung cancer.
three-Amino-1-hydroxyadamantane (CAS 702-eighty two-nine): This compound is involved in the synthesis of adamantane derivatives, which 17b)-7-[9-[(4 have a variety of apps, such as antiviral Homes.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for kind two diabetes that inhibits the enzyme DPP-4 to manage blood sugar levels.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is associated with the synthesis of varied gluconic acid derivatives, that happen to be Utilized in meals, pharmaceutical, and industrial apps.
Canagliflozin Intermediate two: A precursor in the synthesis of canagliflozin, a medication used to deal with sort two diabetes by inhibiting sodium-glucose co-transporter FULVESTRANT INTERMEDIATES--4(N-4) two (SGLT2).